Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hedgehog pathway as a drug target: Smoothened inhibitors in development

1 Mar 2012

Abstract excerpt

Emerging laboratory and clinical investigations demonstrate that Hedgehog signaling (Hh) represents a novel therapeutic target in various human cancers. This conserved signaling pathway precisely regulates self-renewal and terminal differentiation in embryonic development, but is typically silenced in adult tissues, with reactivation usually only during tissue repair. Aberrant Hh pathway signaling has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Hedgehog Signaling Pathway Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22500124
DOI: 10.2147/ott.s21957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hedgehog pathway as a drug target: Smoothened inhibitors in developmentPMID 22500124Read ↗

Beyond cyclopamine: Targeting Hedgehog signaling for cancer interventionSemantic proximity Read ↗

Hedgehog pathway inhibitors: a patent review (2009 – present)Semantic proximity Read ↗

Design of Hedgehog pathway inhibitors for cancer treatmentSemantic proximity Read ↗

Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignanciesSemantic proximity Read ↗

The Utility of Hedgehog Signaling Pathway Inhibition for CancerSemantic proximity Read ↗

Next-Generation Hedgehog/GLI Pathway Inhibitors for Cancer TherapySemantic proximity Read ↗

Unraveling the therapeutic potential of the Hedgehog pathway in cancer.Semantic proximity Read ↗

Hedgehog signaling pathway as a therapeutic target in various types of cancer.Semantic proximity Read ↗

Molecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem CellsSemantic proximity Read ↗

New prospects for drug development: the hedgehog pathway revealed. Focus on hematologic malignancies.Semantic proximity Read ↗

Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers.Semantic proximity Read ↗

Hedgehog signaling and the glioma-associated oncogene in cancer radioresistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.