Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Scube2 mediates Hedgehog signalling in the zebrafish embryo.

Developmental biology - 1 Jun 2006

Hollway Georgina E, Maule John, Gautier Philippe, Evans Timothy M, Keenan David G, Lohs Claudia, Fischer Danielle, Wicking Carol, Currie Peter D

Abstract excerpt

The Hedgehog family of secreted morphogens specifies the fate of a large number of different cell types within invertebrate and vertebrate embryos, including the muscle cell precursors of the embryonic myotome of zebrafish. Formation of Hedgehog-sensitive muscle fates is disrupted within homozygous zebrafish mutants of the "you"-type class, the majority of which disrupt components of the Hedgehog (HH) signal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryo, Nonmammalian
Share to Extracellular Matrix Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Receptors, Cell Surface

Share to Receptors, G-Protein-Coupled

Share to Smoothened Receptor

Share to Zebrafish

Share to Zebrafish Proteins

Source

Identifiers

PMID: 16626681
DOI: 10.1016/j.ydbio.2006.02.032

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Scube2 mediates Hedgehog signalling in the zebrafish embryo.PMID 16626681Read ↗

Scube activity is necessary for Hedgehog signal transduction in vivo.Semantic proximity Read ↗

The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling.Semantic proximity Read ↗

Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humansSemantic proximity Read ↗

C2cd3 is required for cilia formation and Hedgehog signaling in mouse.Semantic proximity Read ↗

Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning.Semantic proximity Read ↗

SCUBE3 (signal peptide-CUB-EGF domain-containing protein 3) modulates fibroblast growth factor signaling during fast muscle development.Semantic proximity Read ↗

Hematopoietic and neural crest defects in zebrafish shoc2 mutants: a novel vertebrate model for Noonan-like syndrome.Semantic proximity Read ↗

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.Semantic proximity Read ↗

<i>Tmed2</i> regulates Smoothened trafficking and Hedgehog signallingSemantic proximity Read ↗

Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects.Semantic proximity Read ↗

A novel truncating variant of GLI2 associated with Culler-Jones syndrome impairs Hedgehog signallingSemantic proximity Read ↗

Bi-allelic Variations of SMO in Humans Cause a Broad Spectrum of Developmental Anomalies Due to Abnormal Hedgehog Signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.