Article
Scube2 mediates Hedgehog signalling in the zebrafish embryo.
Developmental biology - 1 Jun 2006
Hollway Georgina E, Maule John, Gautier Philippe, Evans Timothy M, Keenan David G, Lohs Claudia, Fischer Danielle, Wicking Carol, Currie Peter D
Abstract excerpt
The Hedgehog family of secreted morphogens specifies the fate of a large number of different cell types within invertebrate and vertebrate embryos, including the muscle cell precursors of the embryonic myotome of zebrafish. Formation of Hedgehog-sensitive muscle fates is disrupted within homozygous zebrafish mutants of the "you"-type class, the majority of which disrupt components of the Hedgehog (HH) signal...
Topics
- Animals
- Embryo, Nonmammalian
- Extracellular Matrix Proteins
- Hedgehog Proteins
- Mutation
- Protein Transport
- Receptors, Cell Surface
- Receptors, G-Protein-Coupled
- Signal Transduction
- Smoothened Receptor