Article

In vitro model of brain endothelial cell barrier reveals alterations induced by Plasmodium blood stage factors

2023-01-06

Abstract excerpt

<title>Abstract</title> <p>Cerebral malaria (CM) is a severe neurological condition caused by <italic>Plasmodium falciparum</italic>. Disruption of the brain-blood barrier (BBB) is a key pathological event leading to brain edema and vascular leakage in both humans and in the mouse model of CM. Interactions of brain endothelial cells with infected red blood cells (iRBCs), and with circulating inflammatory mediator...

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Literature Corpus work: 3221ab10-e3f1-5a9a-bf7b-57d94c81bd7c
DOI: 10.21203/rs.3.rs-2447390/v1

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