Back to search

Article

<i>Plasmodium falciparum</i> hemozoin-associated biomolecules induce brain endothelial cell barrier disruption in an in vitro model of cerebral malaria

2026-03-13

Abstract excerpt

<h4>ABSTRACT</h4> Cerebral malaria is a major complication of Plasmodium falciparum infection that occurs upon the sequestration of infected red blood cells (iRBCs) in brain capillaries, resulting in the loss of endothelial barrier integrity, brain swelling, and frequently long-term sequelae or death. P. falciparum -iRBCs cause the disruption of human brain microvascular endothelial cell barrier integrity in vi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ca06595d-13b9-5c76-b0ec-bafc4dbfb678
DOI
10.64898/2026.03.12.711413
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
<i>Plasmodium falciparum</i> hemozoin-associated biomolecules induce brain endothelial cell barrier disruption in an in vitro model of cerebral malariaDOI 10.64898/2026.03.12.711413
<i>Plasmodium falciparum</i> egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier modelSemantic proximity
In vitro model of brain endothelial cell barrier reveals alterations induced by Plasmodium blood stage factorsSemantic proximity
Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malariaSemantic proximity
Testing the effect of PAR1 inhibitors on Plasmodium falciparum-induced loss of endothelial cell barrier functionSemantic proximity
<i>Plasmodium falciparum</i> impairs Ang-1 secretion by pericytes in a 3D brain microvessel modelSemantic proximity
Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier modelSemantic proximity
Transcriptional responses of brain endothelium to <i>Plasmodium falciparum</i> patient-derived isolates <i>in vitro</i>Semantic proximity
A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malariaSemantic proximity
Febrile temperature enhances <i>Plasmodium falciparum</i> cytoadhesion by disrupting the endothelial glycocalyxSemantic proximity
Platelet-endothelial cell interactions in cerebral malaria: the end of a cordial understanding.Semantic proximity
HNE produced by the malaria parasite<i>Plasmodium falciparum</i>generates HNE–protein adducts and decreases erythrocyte deformabilitySemantic proximity
Cerebral Malaria Pathogenesis: Revisiting Parasite and Host ContributionsSemantic proximity
Select a neighboring publication to make it the new centre.