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Article

Testing the effect of PAR1 inhibitors on Plasmodium falciparum-induced loss of endothelial cell barrier function

2020-07-07

Abstract excerpt

<h4>Background: </h4> Sequestration and cytoadherence of Plasmodium falciparum -infected erythrocytes (IE) to microvascular endothelium alters endothelial barrier function and plays a role in the pathogenesis of severe malaria. Binding of IE is mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1) and the PfEMP1 variants that binds to endothelial protein C receptor (EPCR) have, in particular, been as...

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Literature Corpus work
599e4184-8acd-577a-8f51-24d0d32b20b2
DOI
10.12688/wellcomeopenres.15602.3
Open publication

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Testing the effect of PAR1 inhibitors on Plasmodium falciparum-induced loss of endothelial cell barrier functionDOI 10.12688/wellcomeopenres.15602.3
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