Article

Brain endothelial cells exposure to malaria parasites links Type I interferon signalling to antigen presentation, immunoproteasome activation, endothelium disruption and cell metabolic adaptation

2022-11-26

Abstract excerpt

<h4>ABSTRACT</h4> Cerebral malaria (CM) lethality is attributable to brain edema induction but the cellular mechanisms involving brain microvascular endothelium in CM pathogenesis are unexplored. Activation of the STING-INFb-CXCL10 axis in brain endothelial cells (BECs) is a prominent component of the innate immune response in cerebral malaria (CM) development in mouse models. Using a T cell-reporter system, we s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fc58e3be-fa32-549e-8ebe-9a895766ea7e
DOI: 10.1101/2022.11.26.518027

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Brain endothelial cells exposure to malaria parasites links Type I interferon signalling to antigen presentation, immunoproteasome activation, endothelium disruption and cell metabolic adaptationDOI 10.1101/2022.11.26.518027Read

The spatiotemporal transcriptional profiling of murine brain during cerebral malaria progression and after artemisinin treatmentSemantic proximity Read

<i>Plasmodium falciparum</i> egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier modelSemantic proximity Read

Inflammation and Cellular Stress Induced Neurological Sequelae of <i>Plasmodium falciparum</i> MalariaSemantic proximity Read

Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier modelSemantic proximity Read

Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein contentSemantic proximity Read

Hemozoin induces Malaria via activation of DNA damage, p38 MAPK and Neurodegenerative Pathways in Human iPSC-derived Neuronal Model of Cerebral MalariaSemantic proximity Read

Irf8-Regulated Genomic Responses Drive Pathological Inflammation during Cerebral MalariaSemantic proximity Read

Therapeutic inhibition of glycolysis preferentially targets pathogenic monocyte subsets and attenuates CNS inflammation in flavivirus encephalitisSemantic proximity Read

Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice.Semantic proximity Read

Deletion of OTUD7B in astrocytes protects against cerebral malaria by inhibiting microvesicle-induced TRAF3/TRAF6-mediated neuroinflammationSemantic proximity Read

In vitro model of brain endothelial cell barrier reveals alterations induced by Plasmodium blood stage factorsSemantic proximity Read

Molecular correlates of experimental cerebral malaria detectable in whole blood.Semantic proximity Read