Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Binding Heterogeneity of Plasmodium falciparum to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1

25 May 2019

Abstract excerpt

Cerebral malaria research has been hindered by the inaccessibility of the brain. Here, we have developed an engineered 3D human brain microvessel model that mimics the blood flow rates and architecture of small blood vessels to study how P. falciparum - infected human erythrocytes attach to brain endothelial cells. By studying parasite lines with different adhesive properties, we show that the malaria parasite...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Malaria Research and Control
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31138740
DOI: 10.1128/mbio.00420-19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Binding Heterogeneity of Plasmodium falciparum to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1PMID 31138740Read ↗

Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malariaSemantic proximity Read ↗

<i>Plasmodium falciparum</i> impairs Ang-1 secretion by pericytes in a 3D brain microvessel modelSemantic proximity Read ↗

In vitro model of brain endothelial cell barrier reveals alterations induced by Plasmodium blood stage factorsSemantic proximity Read ↗

Transcriptional responses of brain endothelium to <i>Plasmodium falciparum</i> patient-derived isolates <i>in vitro</i>Semantic proximity Read ↗

Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral MalariaSemantic proximity Read ↗

Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier modelSemantic proximity Read ↗

Platelet-endothelial cell interactions in cerebral malaria: the end of a cordial understanding.Semantic proximity Read ↗

A restricted subset of <i>var</i> genes mediates adherence of <i>Plasmodium falciparum</i> -infected erythrocytes to brain endothelial cellsSemantic proximity Read ↗

Febrile temperature enhances <i>Plasmodium falciparum</i> cytoadhesion by disrupting the endothelial glycocalyxSemantic proximity Read ↗

Evidence of promiscuous endothelial binding by P lasmodium falciparum ‐infected erythrocytesSemantic proximity Read ↗

Dynamic interactions ofPlasmodiumspp. with vascular endotheliumSemantic proximity Read ↗

<i>Plasmodium falciparum</i> egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.