Article

<i>Plasmodium falciparum</i> impairs Ang-1 secretion by pericytes in a 3D brain microvessel model

2024-03-29

Abstract excerpt

Disruption of the vascular protective angiopoietin-Tie axis is common in cerebral malaria (CM) patients, who display elevated angiopoietin-2 (Ang-2) and reduced angiopoietin-1 (Ang-1) blood concentrations. The role of pericytes in CM pathogenesis remains unexplored, despite being a major source of brain Ang-1 secretion and evidence of pericyte damage observed in CM postmortem samples. Here we engineered a human 3D...

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Literature Corpus work: fc09ed0e-6c41-5f5e-afe8-0ebc7bce409f
DOI: 10.1101/2024.03.29.587334

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