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<i>Plasmodium falciparum</i> egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model

2024-10-16

Abstract excerpt

Cerebral malaria is a severe neurovascular complication of Plasmodium falciparum infection, with high mortality rates even after treatment with effective antimalarials. Limitations in current experimental models have hindered our knowledge of the disease. We developed a 3D blood-brain barrier (BBB) model with enhanced barrier properties using primary brain endothelial cells, astrocytes and pericytes. Exposure to...

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Literature Corpus work
1159c04c-cb59-52fa-8f42-55b2990089ff
DOI
10.1101/2024.10.15.618439
Open publication

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<i>Plasmodium falciparum</i> egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier modelDOI 10.1101/2024.10.15.618439
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