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Therapy-Related Myeloid Neoplasms: Complex Interactions among Cytotoxic Therapies, Genetic Factors, and Aberrant Microenvironment.

Blood cancer discovery - 1 Nov 2024

Singhal Deepak, Kutyna Monika M, Hahn Christopher N, Shah Mithun Vinod, Hiwase Devendra K

Abstract excerpt

Therapy-related myeloid neoplasm (t-MN), characterized by its association with prior exposure to cytotoxic therapy, remains poorly understood and is a major impediment to long-term survival even in the era of novel targeted therapies due to its aggressive nature and treatment resistance. Previously, cytotoxic therapy-induced genomic changes in hematopoietic stem cells were considered sine qua non in pathogenesis;...

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Identifiers

PMID: 39422544
DOI: 10.1158/2643-3230.BCD-24-0103
PMCID: PMC11528189

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