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Therapy-Related Myeloid Neoplasm: Biology and Mechanistic Aspects of Malignant Progression

10 May 2024

Abstract excerpt

Therapy-related myeloid neoplasms (t-MN) arise after a documented history of chemo/radiotherapy as treatment for an unrelated condition and account for 10-20% of myelodysplastic syndromes and acute myeloid leukemia. T-MN are characterized by a specific genetic signature, aggressive features and dismal prognosis. The nomenclature and the subsets of these conditions have changed frequently over time, and despite...

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PMID: 38791019
DOI: 10.3390/biomedicines12051054

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