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Article

Clonal hematopoiesis-derived therapy-related myeloid neoplasms after autologous hematopoietic stem cell transplant for lymphoid and non-lymphoid disorders.

Leukemia - 1 Jun 2024

Awada Hussein, Gurnari Carmelo, Visconte Valeria, Durmaz Arda, Kuzmanovic Teodora, Awada Hassan, Tu Zheng Jin, Cook James R, Bolwell Brian J, Sobecks Ronald, Kalaycio Matt, Bosler David, Maciejewski Jaroslaw P

Abstract excerpt

Therapy-related myeloid neoplasms (tMN) are complications of cytotoxic therapies. Risk of tMN is high in recipients of autologous hematopoietic stem cell transplantation (aHSCT). Acquisition of genomic mutations represents a key pathogenic driver but the origins, timing and dynamics, particularly in the context of preexisting or emergent clonal hematopoiesis (CH), have not been sufficiently clarified. We studied...

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Share to Clonal Hematopoiesis
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myeloproliferative Disorders

Share to Neoplasms, Second Primary

Share to Protein Phosphatase 2C

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Source

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Identifiers

PMID: 38684821
DOI: 10.1038/s41375-024-02258-y
PMCID: PMC11147764

Genes

PPM1D
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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