Article
Genomic Evolution of Myeloproliferative Neoplasms and Therapy-Associated Mutagenesis.
Cancer discovery - 1 Sept 2026
Leongamornlert Daniel, Lee Joe, Kamizela Aleksandra E, To Ken, Myers Daniel, Williams Nicholas, Nyamondo Kudzai, Wang Xin, Guo Jing, Dissanayake Ruchira K, Price Jane, Durrani Amer J, Lambert Jonathan, Spencer Chapman Michael, Pimanda John E, Baxter E Joanna, Green Anthony R, Godfrey Anna L, Nangalia Jyoti
Abstract excerpt
Philadelphia-negative myeloproliferative neoplasms are chronic blood neoplasms. Treatments control blood counts, but disease can progress to myelofibrosis or acute myeloid leukemia. We performed longitudinal whole-genome and targeted sequencing in 30 patients, integrating clonal dynamics with 7,986 blood counts and clinical histories. Distinct evolutionary patterns distinguished stable from progressive disease,...
Read the complete abstract on PubMedTopics
- Humans
- Myeloproliferative Disorders
- Mutagenesis
- Evolution, Molecular
- Genomics