Mapping kidney trait heritability to individual cells reveals disease-specific remodeling of genetic risk architecture

Abstract excerpt

Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with kidney function and disease, yet the cell-type-specific mechanisms through which these variants act remain largely unknown. Here, we construct the Kidney Genetic Disease Cell Atlas by applying single-cell disease relevance scoring (scDRS) to map GWAS signals for six kidney-related traits-estimated glomerular filtration...

Topics

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• Genome-Wide Association Study
• Glomerular Filtration Rate
• Kidney Failure, Chronic
• Polymorphism, Single Nucleotide
• Renal Insufficiency, Chronic
• Sequence Analysis, RNA
• Single-Cell Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

13801f0a-b5fb-5540-b35a-b9a059c92c56

DOI

10.64898/2026.04.12.717976