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Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

28 Dec 2018

Abstract excerpt

Chronic kidney disease (CKD) affects ~10% of the global population, with considerable ethnic differences in prevalence and aetiology. We assemble genome-wide association studies of estimated glomerular filtration rate (eGFR), a measure of kidney function that defines CKD, in 312,468 individuals of diverse ancestry. We identify 127 distinct association signals with homogeneous effects on eGFR across ancestries and...

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PMID: 30604766
DOI: 10.1038/s41467-018-07867-7

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