Article
Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants.
Science (New York, N.Y.) - 7 Feb 2025
Liu Hongbo, Abedini Amin, Ha Eunji, Ma Ziyuan, Sheng Xin, Dumoulin Bernhard, Qiu Chengxiang, Aranyi Tamas, Li Shen, Dittrich Nicole, Chen Hua-Chang, Tao Ran, Tarng Der-Cherng, Hsieh Feng-Jen, Chen Shih-Ann, Yang Shun-Fa, Lee Mei-Yueh, Kwok Pui-Yan, Wu Jer-Yuarn, Chen Chien-Hsiun, Khan Atlas, Limdi Nita A, Wei Wei-Qi, Walunas Theresa L, Karlson Elizabeth W, Kenny Eimear E, Luo Yuan, Kottyan Leah, Connolly John J, Jarvik Gail P, Weng Chunhua, Shang Ning, Cole Joanne B, Mercader Josep M, Mandla Ravi, Majarian Timothy D, Florez Jose C, Haas Mary E, Lotta Luca A, Drivas Theodore G, Vy Ha My T, Nadkarni Girish N, Wiley Laura K, Wilson Melissa P, Gignoux Christopher R, Rasheed Humaira, Thomas Laurent F, Åsvold Bjørn Olav, Brumpton Ben M, Hallan Stein I, Hveem Kristian, Zheng Jie, Hellwege Jacklyn N, Zawistowski Matthew, Zöllner Sebastian, Franceschini Nora, Hu Hailong, Zhou Jianfu, Kiryluk Krzysztof, Ritchie Marylyn D, Palmer Matthew, Edwards Todd L, Voight Benjamin F, Hung Adriana M, Susztak Katalin
Abstract excerpt
Kidney dysfunction is a major cause of mortality, but its genetic architecture remains elusive. In this study, we conducted a multiancestry genome-wide association study in 2.2 million individuals and identified 1026 (97 previously unknown) independent loci. Ancestry-specific analysis indicated an attenuation of newly identified signals on common variants in European ancestry populations and the power of...
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