Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity.

doi:10.1016/j.ajhg.2016.07.012

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Article

Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity.

American journal of human genetics - 1 Sept 2016

Mahajan Anubha, Rodan Aylin R, Le Thu H, Gaulton Kyle J, Haessler Jeffrey, Stilp Adrienne M, Kamatani Yoichiro, Zhu Gu, Sofer Tamar, Puri Sanjana, Schellinger Jeffrey N, Chu Pei-Lun, Cechova Sylvia, van Zuydam Natalie, Arnlov Johan, Flessner Michael F, Giedraitis Vilmantas, Heath Andrew C, Kubo Michiaki, Larsson Anders, Lindgren Cecilia M, Madden Pamela A F, Montgomery Grant W, Papanicolaou George J, Reiner Alex P, Sundström Johan, Thornton Timothy A, Lind Lars, Ingelsson Erik, Cai Jianwen, Martin Nicholas G, Kooperberg Charles, Matsuda Koichi, Whitfield John B, Okada Yukinori, Laurie Cathy C, Morris Andrew P, Franceschini Nora

Abstract excerpt

We analyzed genome-wide association studies (GWASs), including data from 71,638 individuals from four ancestries, for estimated glomerular filtration rate (eGFR), a measure of kidney function used to define chronic kidney disease (CKD). We identified 20 loci attaining genome-wide-significant evidence of association (p < 5 × 10(-8)) with kidney function and highlighted that allelic effects on eGFR at lead SNPs are...

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Identifiers

PMID: 27588450
DOI: 10.1016/j.ajhg.2016.07.012
PMCID: PMC5011075

Genes

NFATC1
RGS14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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