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Article

Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.

Nature genetics - 1 Jul 2022

Liu Hongbo, Doke Tomohito, Guo Dong, Sheng Xin, Ma Ziyuan, Park Joseph, Vy Ha My T, Nadkarni Girish N, Abedini Amin, Miao Zhen, Palmer Matthew, Voight Benjamin F, Li Hongzhe, Brown Christopher D, Ritchie Marylyn D, Shu Yan, Susztak Katalin

Abstract excerpt

More than 800 million people suffer from kidney disease, yet the mechanism of kidney dysfunction is poorly understood. In the present study, we define the genetic association with kidney function in 1.5 million individuals and identify 878 (126 new) loci. We map the genotype effect on the methylome in 443 kidneys, transcriptome in 686 samples and single-cell open chromatin in 57,229 kidney cells. Heritability...

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Identifiers

PMID: 35710981
DOI: 10.1038/s41588-022-01097-w
PMCID: PMC11626562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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