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Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank

2016-10-12

Abstract excerpt

Major depressive disorder (MDD), schizophrenia (SCZ) and bipolar disorder (BP) are common, disabling and heritable psychiatric diseases with a complex overlapping polygenic architecture. Individuals with these disorders, as well as their unaffected relatives, show widespread structural differences in corticostriatal and limbic networks. Structural variation in many of these brain regions is also heritable and poly...

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Literature Corpus work
31bd687e-5d62-595a-9649-011f73915c7f
DOI
10.1101/080283
Open publication

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