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Article

Genetic risk for bipolar disorder and schizophrenia predicts structure and function of the ventromedial prefrontal cortex.

Journal of psychiatry & neuroscience : JPN - 22 Jul 2021

Abé Christoph, Petrovic Predrag, Ossler William, Thompson William H, Liberg Benny, Song Jie, Bergen Sarah E, Sellgren Carl M, Fransson Peter, Ingvar Martin, Landén Mikael

Abstract excerpt

BACKGROUND: Bipolar disorder is highly heritable and polygenic. The polygenic risk for bipolar disorder overlaps with that of schizophrenia, and polygenic scores are normally distributed in the population. Bipolar disorder has been associated with structural brain abnormalities, but it is unknown how these are linked to genetic risk factors for psychotic disorders. METHODS: We tested whether polygenic risk scores...

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Identifiers

PMID: 34291628
DOI: 10.1503/jpn.200165
PMCID: PMC8519489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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