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Article

Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank.

Scientific reports - 10 Feb 2017

Reus L M, Shen X, Gibson J, Wigmore E, Ligthart L, Adams M J, Davies G, Cox S R, Hagenaars S P, Bastin M E, Deary I J, Whalley H C, McIntosh A M

Abstract excerpt

Major depressive disorder (MDD), schizophrenia (SCZ) and bipolar disorder (BP) are common, disabling and heritable psychiatric diseases with a complex overlapping polygenic architecture. Individuals with these disorders, as well as their unaffected relatives, show widespread structural differences in corticostriatal and limbic networks. Structural variation in many of these brain regions is also heritable and...

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PMID: 28186152
DOI: 10.1038/srep42140
PMCID: PMC5301496

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