Article
Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank.
Biological psychiatry. Cognitive neuroscience and neuroimaging - 1 Jan 2019
Barbu Miruna C, Zeng Yanni, Shen Xueyi, Cox Simon R, Clarke Toni-Kim, Gibson Jude, Adams Mark J, Johnstone Mandy, Haley Chris S, Lawrie Stephen M, Deary Ian J, McIntosh Andrew M, Whalley Heather C
Abstract excerpt
BACKGROUND: Major depressive disorder is a clinically heterogeneous psychiatric disorder with a polygenic architecture. Genome-wide association studies have identified a number of risk-associated variants across the genome and have reported growing evidence of NETRIN1 pathway involvement. Stratifying disease risk by genetic variation within the NETRIN1 pathway may provide important routes for identification of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.