Article

A binding site for phosphoinositides described by multiscale simulations explains their modulation of voltage gated sodium channels

2023-07-17

Abstract excerpt

Voltage gated sodium channels (Na v ) are membrane proteins which open to facilitate the inward flux of sodium ions into excitable cells. In response to stimuli, Na v channels transition from the resting, closed state to an open, conductive state, before rapidly inactivating. Dysregulation of this functional cycle due to mutations causes diseases including epilepsy, pain conditions and cardiac disorders, making...

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Literature Corpus work: 319cb6dc-aa03-52ef-8784-272f861f5b70
DOI: 10.1101/2023.07.16.547149

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