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Article

Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation.

Scientific reports - 15 Oct 2015

Chen Liping, Zhang Qiansen, Qiu Yunguang, Li Zanyuan, Chen Zhuxi, Jiang Hualiang, Li Yang, Yang Huaiyu

Abstract excerpt

Published studies of lipid-protein interactions have mainly focused on lipid binding to an individual site of the protein. Here, we show that a lipid can migrate between different binding sites in a protein and this migration modulates protein function. Voltage-gated potassium (Kv) channels have several potential binding sites for phosphatidylinositol-4,5-bisphosphate (PIP2). Our molecular dynamics (MD)...

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Source

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Identifiers

PMID: 26469389
DOI: 10.1038/srep15079
PMCID: PMC4606798

Genes

KCNQ2
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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