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Article

A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function.

The Journal of biological chemistry - 21 Aug 2015

Kaur Gurjot, Pinggera Alexandra, Ortner Nadine J, Lieb Andreas, Sinnegger-Brauns Martina J, Yarov-Yarovoy Vladimir, Obermair Gerald J, Flucher Bernhard E, Striessnig Jörg

Abstract excerpt

L-type voltage-gated Ca(2+) channels (LTCCs) regulate many physiological functions like muscle contraction, hormone secretion, gene expression, and neuronal excitability. Their activity is strictly controlled by various molecular mechanisms. The pore-forming α1-subunit comprises four repeated domains (I-IV), each connected via an intracellular linker. Here we identified a polybasic plasma membrane binding motif,...

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Identifiers

PMID: 26100638
DOI: 10.1074/jbc.M115.645671
PMCID: PMC4543666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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