Article

PIP <sub>2</sub> -dependent coupling of voltage sensor and pore domains in K <sub>v</sub> 7.2

2021-05-11

Abstract excerpt

Phosphatidylinositol-4,5-bisphosphate (PIP 2 ) is a signaling lipid which regulates voltage-gated K v 7/ KCNQ potassium channels. Altered PIP 2 sensitivity of neuronal K v 7.2 channel is involved in KCNQ2 epileptic encephalopathy. However, the molecular action of PIP 2 on K v 7.2 gating remains largely elusive. Here, we use molecular dynamics simulations and electrophysiology to characterize PIP 2 binding...

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Literature Corpus work: 8435d692-7b76-5e7c-97b4-ef44a939df6e
DOI: 10.1101/2021.05.11.443644

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