Article

Simulating PIP <sub>2</sub> -induced gating transitions in Kir6.2 channels

2021-05-21

Abstract excerpt

ATP-sensitive potassium (K ATP ) channels consist of an inwardly rectifying K + channel (Kir6.2) pore, to which four ATP-sensitive sulfonylurea receptor (SUR) domains are attached, thereby coupling K + permeation directly to the metabolic state of the cell. Dysfunction is linked to neonatal diabetes and other diseases. K + flux through these channels is controlled by conformational changes in the helix bundle...

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Literature Corpus work: 73c26e6e-9504-5c82-9ba9-1bdc7a46aa39
DOI: 10.1101/2021.05.20.445012

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