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Article

A dual polybasic motif determines phosphoinositide binding and regulation in the P2X channel family.

PloS one - 1 Jan 2012

Bernier Louis-Philippe, Blais Dominique, Boué-Grabot Éric, Séguéla Philippe

Abstract excerpt

Phosphoinositides modulate the function of several ion channels, including most ATP-gated P2X receptor channels in neurons and glia, but little is known about the underlying molecular mechanism. We identified a phosphoinositide-binding motif formed of two clusters of positively charged amino acids located on the P2X cytosolic C-terminal domain, proximal to the second transmembrane domain. For all known P2X...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22792379
DOI: 10.1371/journal.pone.0040595
PMCID: PMC3394732

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