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Article

Pacemaking by HCN channels requires interaction with phosphoinositides.

Neuron - 21 Dec 2006

Zolles Gerd, Klöcker Nikolaj, Wenzel Daniela, Weisser-Thomas Jutta, Fleischmann Bernd K, Roeper Jochen, Fakler Bernd

Abstract excerpt

Hyperpolarization-activated, cyclic-nucleotide-gated (HCN) channels mediate the depolarizing cation current (termed I(h) or I(f)) that initiates spontaneous rhythmic activity in heart and brain. This function critically depends on the reliable opening of HCN channels in the subthreshold voltage-r...

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Source

Identifiers

PMID: 17178405
DOI: 10.1016/j.neuron.2006.12.005

Genes

PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17178405-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Pacemaking by HCN channels requires interaction with phosphoinositides.PMID 17178405Read ↗

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Differential contribution of HCN1 and HCN4 to the synchronisation of sinoatrial pacemaker cellsSemantic proximity Read ↗

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