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Article

Pacemaking by HCN channels requires interaction with phosphoinositides.

Neuron - 21 Dec 2006

Zolles Gerd, Klöcker Nikolaj, Wenzel Daniela, Weisser-Thomas Jutta, Fleischmann Bernd K, Roeper Jochen, Fakler Bernd

Abstract excerpt

Hyperpolarization-activated, cyclic-nucleotide-gated (HCN) channels mediate the depolarizing cation current (termed I(h) or I(f)) that initiates spontaneous rhythmic activity in heart and brain. This function critically depends on the reliable opening of HCN channels in the subthreshold voltage-range. Here we show that activation of HCN channels at physiologically relevant voltages requires interaction with...

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PMID: 17178405
DOI: 10.1016/j.neuron.2006.12.005

Genes

PIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Pacemaking by HCN channels requires interaction with phosphoinositides.PMID 17178405Read ↗

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Differential contribution of HCN1 and HCN4 to the synchronisation of sinoatrial pacemaker cellsSemantic proximity Read ↗

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