Article

PIP <sub>2</sub> stabilizes Na <sub>V</sub> 1.5 gating and links receptor signaling to cardiac late sodium current

2026-07-03

Abstract excerpt

The cardiac sodium channel Na V 1.5 initiates each heartbeat by generating the rapid depolarizing upstroke of the action potential. Dysregulation of Na V 1.5 gating can produce cardiac arrhythmias by slowing inactivation, increasing late sodium current (I Na,L ), and impairing electrical stability. Here, we show that phosphatidylinositol-4,5-bisphosphate (PIP 2 ) is a critical membrane cofactor that stabilizes...

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Literature Corpus work: b6aa6251-cc0f-583e-be71-16b468b61337
DOI: 10.64898/2026.06.29.735321

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