Article

Functional crosstalk between phosphorylation and disease-causing mutations in the cardiac sodium channel Na <sub>v</sub> 1.5

2020-12-11

Abstract excerpt

The voltage-gated sodium channel Na v 1.5 initiates the cardiac action potential. Alterations of its activation and inactivation properties due to mutations can cause severe, life-threatening arrhythmias. Yet despite intensive research efforts, many functional aspects of this cardiac channel remain poorly understood. For instance, Na v 1.5 undergoes extensive post-translational modification in vivo , but the fu...

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Literature Corpus work: 1bbe26c4-d494-5d9a-b295-d375927beaeb
DOI: 10.1101/2020.12.11.417683

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