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Article

LRRC8A regulates hypotonicity-induced NLRP3 inflammasome activation

2020-06-12

Abstract excerpt

The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is frequently associated with the damaging inflammation of non-communicable disease states and is considered a therapeutic target. However, there is much regarding the mechanism of NLRP3 activation that remains unknown. Chloride efflux is suggested as a...

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Identifiers and source

Literature Corpus work
c0bfa7d5-091e-54ea-9768-b333d3dfa7c4
DOI
10.1101/2020.06.11.146225
Open publication

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LRRC8A regulates hypotonicity-induced NLRP3 inflammasome activationDOI 10.1101/2020.06.11.146225
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