Article

Release of acidic store calcium is required for effective priming of the NLRP3 inflammasome

2022-01-06

Abstract excerpt

The lysosome is a dynamic signaling organelle that is critical for cell functioning. It is a regulated calcium store that can contribute to Ca 2+ -regulated processes via both local calcium release and more globally by influencing ER Ca 2+ release. Here, we provide evidence from studies of an authentic mouse model of the lysosomal storage disease Niemann-Pick Type C (NPC) that has reduced lysosomal Ca 2+ levels...

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Identifiers and source

Literature Corpus work: 921c747e-c48e-5dbf-bb20-688012452fdd
DOI: 10.1101/2022.01.06.475262

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