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Article

Unfolding neural diversity: how dynamic three-dimensional genome architecture regulates brain function and disease.

Molecular psychiatry - 1 Aug 2025

Logeman Brandon L, Grieco Steven F, Holmes Todd C, Xu Xiangmin

Abstract excerpt

The advent of single cell multi-omic technologies has ushered in a revolution in how we study the impact of three-dimensional genome organization on brain cellular composition and function. Transcriptomic and epigenomic studies reveal enormous cellular diversity that is present in mammalian nervous systems, raising the question, "how does this diversity arise and for what is its use?" Advances in the field of...

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PMID: 40410418
DOI: 10.1038/s41380-025-03056-3
PMCID: PMC12228417

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