Article

Templating of Monomeric Alpha-Synuclein Induces Inflammation and SNpc Dopamine Neuron Death in a Genetic Mouse Model of Synucleinopathy.

2024-11-20

Abstract excerpt

<title>Abstract</title> <p>While the etiology of most cases of Parkinson’s disease (PD) are idiopathic, it has been estimated that 5-10% of PD arise from known genetic mutations. The first mutations described that leads to the development of an autosomal dominant form of PD are in the SNCA gene that codes for the protein alpha-synuclein (α-syn). α-syn is an abundant presynaptic protein that is natively disordered...

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Literature Corpus work: 6deeb21b-1655-5594-b52c-c8d527ab2ed0
DOI: 10.21203/rs.3.rs-5269499/v1

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