Article

From Correlation to Causation: Cell-Type-Specific Gene Regulatory Networks in Alzheimer’s Disease

2025-09-25

Abstract excerpt

<h4>INTRODUCTION</h4> Alzheimer’s disease (AD) involves complex regulatory disruptions across multiple brain cell types, yet a comprehensive understanding of the intracellular causal mechanisms remains unclear. <h4>METHODS</h4> We presented an integrative analysis framework using single-nucleus transcriptomic with matched subject-level genotype data from 272 human AD in the Religious Orders Study and the Rush Me...

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Literature Corpus work: 3152d40e-321c-59e0-a82d-ba8d11b2fbf1
DOI: 10.1101/2025.09.25.674923

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