Article

Counterfactual inference for single-cell gene expression analysis

2021-01-26

Abstract excerpt

<h4>Finding: </h4> a causal gene is a fundamental problem in genomic medicine. We present a causal inference framework that prioritizes disease genes by adjusting confounders without prior knowledge of control variables. We demonstrate that our method substantially improves statistical power in simulations and real-world data analysis of 70k brain cells collected for dissecting Alzheimer’s disease. We identified t...

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Literature Corpus work: 536e51db-0921-5534-8f9b-98dd7d945da9
DOI: 10.1101/2021.01.21.21249765

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