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Article

A Mechanistic Model for Colibactin-Induced Genotoxicity.

Journal of the American Chemical Society - 7 Dec 2016

Healy Alan R, Nikolayevskiy Herman, Patel Jaymin R, Crawford Jason M, Herzon Seth B

Abstract excerpt

Precolibactins and colibactins represent a family of natural products that are encoded by the clb gene cluster and are produced by certain commensal, extraintestinal, and probiotic E. coli. clb+ E. coli induce megalocytosis and DNA double-strand breaks in eukaryotic cells, but paradoxically, this gene cluster is found in the probiotic Nissle 1917. Evidence suggests precolibactins are converted to genotoxic...

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Identifiers

PMID: 27934011
DOI: 10.1021/jacs.6b10354
PMCID: PMC5359767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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