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Article

An inter-chromosomal transcription hub activates the unfolded protein response in plasma cells

2018-04-06

Abstract excerpt

Previous studies have indicated that the transcription signature of antibody-secreting cells is closely associated with the induction of the unfolded protein response pathway (UPR). Here we have used genome-wide and single cell analyses to examine the folding patterns of plasma cell genomes. We found that plasma cells adopt a cartwheel configuration and undergo large-scale changes in chromatin folding at genomic r...

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Literature Corpus work
8cca9d0e-3305-51d2-b278-7de500c70a85
DOI
10.1101/295915
Open publication

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An inter-chromosomal transcription hub activates the unfolded protein response in plasma cellsDOI 10.1101/295915
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