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Integrative single-cell chromatin and transcriptome analysis of human plasma cell differentiation

21 Apr 2024

Abstract excerpt

ABSTRACT: Plasma cells (PCs) are highly specialized cells representing the end stage of B-cell differentiation. We have shown that PC differentiation can be reproduced in vitro using elaborate culture systems. The molecular changes occurring during PC differentiation are recapitulated in this in vitro differentiation model. However, a major challenge exists to decipher the spatiotemporal epigenetic and...

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PMID: 38643512
DOI: 10.1182/blood.2023023237

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