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Article

European and African ancestry-specific plasma protein-QTL and metabolite-QTL analyses identify ancestry-specific T2D effector proteins and metabolites.

Nature communications - 11 Aug 2025

Yang Chengran, Gorijala Priyanka, Timsina Jigyasha, Wang Lihua, Liu Menghan, Wang Ciyang, Brock William, Wang Yueyao, Urano Fumihiko, Sung Yun Ju, Cruchaga Carlos

Abstract excerpt

In this study, we generated and integrated plasma proteomics and metabolomics with the genotype datasets of over 2300 European (EUR) and 400 African (AFR) ancestries to identify ancestry-specific multi-omics quantitative trait loci (QTLs). In total, we mapped 954 AFR pQTLs, 2848 EUR pQTLs, 65 AFR mQTLs, and 490 EUR mQTLs. We further applied these QTLs to ancestry-stratified type-2 diabetes (T2D) risk to pinpoint...

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Identifiers

PMID: 40789849
DOI: 10.1038/s41467-025-62463-w
PMCID: PMC12339932

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