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Article

Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies.

Nature genetics - 1 May 2022

Zhang Jingning, Dutta Diptavo, Köttgen Anna, Tin Adrienne, Schlosser Pascal, Grams Morgan E, Harvey Benjamin, Yu Bing, Boerwinkle Eric, Coresh Josef, Chatterjee Nilanjan

Abstract excerpt

Improved understanding of genetic regulation of the proteome can facilitate identification of the causal mechanisms for complex traits. We analyzed data on 4,657 plasma proteins from 7,213 European American (EA) and 1,871 African American (AA) individuals from the Atherosclerosis Risk in Communities study, and further replicated findings on 467 AA individuals from the African American Study of Kidney Disease and...

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Identifiers

PMID: 35501419
DOI: 10.1038/s41588-022-01051-w
PMCID: PMC9236177

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