Article
Protein prediction for trait mapping in diverse populations.
PloS one - 1 Jan 2022
Schubert Ryan, Geoffroy Elyse, Gregga Isabelle, Mulford Ashley J, Aguet Francois, Ardlie Kristin, Gerszten Robert, Clish Clary, Van Den Berg David, Taylor Kent D, Durda Peter, Johnson W Craig, Cornell Elaine, Guo Xiuqing, Liu Yongmei, Tracy Russell, Conomos Matthew, Blackwell Tom, Papanicolaou George, Lappalainen Tuuli, Mikhaylova Anna V, Thornton Timothy A, Cho Michael H, Gignoux Christopher R, Lange Leslie, Lange Ethan, Rich Stephen S, Rotter Jerome I, Manichaikul Ani, Im Hae Kyung, Wheeler Heather E
Abstract excerpt
Genetically regulated gene expression has helped elucidate the biological mechanisms underlying complex traits. Improved high-throughput technology allows similar interrogation of the genetically regulated proteome for understanding complex trait mechanisms. Here, we used the Trans-omics for Precision Medicine (TOPMed) Multi-omics pilot study, which comprises data from Multi-Ethnic Study of Atherosclerosis...
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