Article

SALL4B not targeted by IMiD is important for SALL4-mediated tumorigenesis

2023-07-07

Abstract excerpt

Immunomodulatory (IMiD) drugs have shown prominent therapeutic activity in hematologic malignancies; however, their use in solid tumors is limited. The oncofetal protein SALL4 is essential for cancer cell survival. While IMiDs can induce SALL4 degradation, they fail to induce cell death in SALL4-expressing cancer cell lines. Here, we observed that this inefficacy arose from their selective degradation of the long...

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Literature Corpus work: 3100a6e3-062a-5d20-aed4-a0193191d3c9
DOI: 10.1101/2023.07.07.548071

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