Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade

14 Nov 2024

Abstract excerpt

Abstract How cancer cells escape immune surveillance and resist immune checkpoint blockade (ICB) remains to be fully elucidated. By screening candidate genes frequently gained in cancer, we identified expression of ubiquitin-like modifier-activating enzyme 1 (UBA1) as being the most negatively correlated with signatures related to effector CD8+ T cells. High UBA1 expression was strongly predictive of treatment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Peptidase Inhibition and Analysis
Share to RNA modifications and cancer
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39540840
DOI: 10.1158/2159-8290.cd-24-0435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint BlockadePMID 39540840Read ↗

Loss of Ubiquitin Ligase STUB1 Amplifies IFNγ-R1/JAK1 Signaling and Sensitizes Tumors to IFNγSemantic proximity Read ↗

STUB1 is an intracellular checkpoint for interferon gamma sensingSemantic proximity Read ↗

UBE2A as a prognostic indicator across human cancers: Insights from multi‑omics and immune landscape analysesSemantic proximity Read ↗

Identification of a ubiquitin related gene signature for predicting prognosis and immune infiltration in breast cancer based on single cell and bulk RNA sequencing analysisSemantic proximity Read ↗

Inhibition of UBE2N in regulatory T-cells boosts immunity against cancerSemantic proximity Read ↗

STUB1/CHIP: New insights in cancer and immunitySemantic proximity Read ↗

Tumor immune checkpoints and their associated inhibitorsSemantic proximity Read ↗

EPDR1 promotes PD-L1 expression and tumor immune evasion by inhibiting TRIM21-dependent ubiquitylation of IkappaB kinase-βSemantic proximity Read ↗

Targeting MDA5 enhances tumor immunity through immunogenic cell death and augments the efficacy of immune checkpoint blockadeSemantic proximity Read ↗

Analysis of Prognostic Value, Immune Escape Significance and Ferroptosis Correlation of Ubiquitination-related Genes UBTD1 in Colorectal CarcinogenesisSemantic proximity Read ↗

A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer targetSemantic proximity Read ↗

USP18 Inhibition Enhances Type I Interferon Signalling and Immune Activation in the Tumour Microenvironment of Triple-Negative Breast CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.