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Article

The Role of Stem Cell Factor SALL4 in Leukemogenesis

1 Jan 2011

Abstract excerpt

SALL4, a member of the SALL gene family, is one of the most important transcriptional regulators of stem cells. It is of particular interest to stem cell biologists because it is linked to the self-renewal of both embryonic stem cells (ESCs) and hematopoietic stem cells (HSCs), and it is involved in human leukemia. In ESCs, the Sall4/Oct4/Nanog core transcriptional network governs the self-renewal and pluripotent...

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PMID: 22150312
DOI: 10.1615/critrevoncog.v16.i1-2.110

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