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Advances Toward Lsd1 Inhibitors for Cancer Therapy

1 Jul 2017

Abstract excerpt

LSD1 has become an important biologically validated epigenetic target for cancer therapy since its identification in 2004. LSD1 mediates many cellular signaling pathways and is involved in the initiation and development of cancers. Aberrant overexpression of LSD1 has been observed in different types of cancers, and inactivation by small molecules suppresses cancer cell differentiation, proliferation, invasion and...

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Share to Epigenetics and DNA Methylation
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PMID: 28722477
DOI: 10.4155/fmc-2017-0068

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