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Article

Roles of SALL2 in tumorigenesis.

Archives of pharmacal research - 1 Feb 2017

Sung Chang K, Yim Hyungshin

Abstract excerpt

The proteins p150Sal2 (product of SALL2) and p53 share growth arrest and pro-apoptotic functions by independently inducing p21Cip1/Waf1 and BAX, and both proteins are targeted by the human papilloma virus E6 protein, leading to blockage of growth arrest in infected cells. Loss of both p53 and Sall2 in mice causes significantly higher mortality and metastasis rates compared with p53 single mutant mice. Therefore,...

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Source

Identifiers

PMID: 27957650
DOI: 10.1007/s12272-016-0874-x

Genes

SALL2
BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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