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Article

Induction of a SALL4-dependency for targeted cancer therapy

2020-07-11

Abstract excerpt

Oncofetal protein SALL4 is critical for tumor cell survival, making it a promising target in cancer therapy. However, it is detectable only in a subset of cancer patients, which limits the therapeutic impact of a SALL4 targeted therapy. Here we report that SALL4 can be activated and/or upregulated pharmacologically by hypomethylating agents, such as 5-Aza-2’-deoxycytidine (DAC), which are used clinically, and that...

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Identifiers and source

Literature Corpus work
74bd54b1-2218-5eed-86a5-86abf4b158ec
DOI
10.1101/2020.07.10.197434
Open publication

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Induction of a SALL4-dependency for targeted cancer therapyDOI 10.1101/2020.07.10.197434
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