Article
Driver Mutation Acquisition in Utero and Childhood Followed By Lifelong Clonal Evolution Underlie Myeloproliferative Neoplasms
2020-11-19
Abstract excerpt
Background Recurrent mutations in cancer-associated genes drive tumour outgrowth, however, the timing of driver mutations and the dynamics of clonal expansion remain largely unknown. Philadelphia-negative myeloproliferative neoplasms (MPN) are unique cancers capturing the earliest stages of tumorigenesis through to disease evolution. Most patients harbor JAK2V617F, present as the only driver mutation or occurring...
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Identifiers and source
- Literature Corpus work
- 30efcf22-4031-5463-8037-7521fa0a2b9f
- DOI
- 10.1182/blood-2020-143813